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Article

Polycomb-dependent Ultrabithorax Hox gene silencing induced by high Ultrabithorax levels in Drosophila.

Development (Cambridge, England) - 1 Oct 2008

Garaulet Daniel L, Foronda David, Calleja Manuel, Sánchez-Herrero Ernesto

Abstract excerpt

The Ultrabithorax (Ubx) gene of Drosophila specifies the third thoracic and first abdominal segments. Ubx expression is controlled by several mechanisms, including negative regulation by its own product. We show here that if Ubx expression levels are inappropriately elevated, overriding the auto-regulatory control, a permanent repression of Ubx is established. This continuous repression becomes independent of the...

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Source

Identifiers

PMID: 18715947
DOI: 10.1242/dev.025809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polycomb-dependent Ultrabithorax Hox gene silencing induced by high Ultrabithorax levels in Drosophila.PMID 18715947Read ↗

Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.Semantic proximity Read ↗

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.Semantic proximity Read ↗

Transvection in the Drosophila Ultrabithorax gene: a Cbx1 mutant allele induces ectopic expression of a normal allele in trans.Semantic proximity Read ↗

The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner.Semantic proximity Read ↗

Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation.Semantic proximity Read ↗

Interactions of Polycomb and trithorax with cis regulatory regions of Ultrabithorax during the development of Drosophila melanogaster.Semantic proximity Read ↗

In situ dissection of a Polycomb response element in Drosophila melanogaster.Semantic proximity Read ↗

Effects of Polycomb group mutations on the expression of Ultrabithorax in the Drosophila visceral mesoderm.Semantic proximity Read ↗

Integration of RNA processing and expression level control modulates the function of the Drosophila Hox gene Ultrabithorax during adult development.Semantic proximity Read ↗

Probes of chromatin accessibility in the Drosophila bithorax complex respond differently to Polycomb-mediated repression.Semantic proximity Read ↗

Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: evidence from elimination, substitution and ectopic expression of specific isoforms.Semantic proximity Read ↗

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