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Article

Indel and Carryforward Correction (ICC): a new analysis approach for processing 454 pyrosequencing data.

Bioinformatics (Oxford, England) - 1 Oct 2013

Deng Wenjie, Maust Brandon S, Westfall Dylan H, Chen Lennie, Zhao Hong, Larsen Brendan B, Iyer Shyamala, Liu Yi, Mullins James I

Abstract excerpt

MOTIVATION: Pyrosequencing technology provides an important new approach to more extensively characterize diverse sequence populations and detect low frequency variants. However, the promise of this technology has been difficult to realize, as careful correction of sequencing errors is crucial to distinguish rare variants (∼1%) in an infected host with high sensitivity and specificity. RESULTS: We developed a new...

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Identifiers

PMID: 23900188
DOI: 10.1093/bioinformatics/btt434
PMCID: PMC3777116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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