Article

Optimized SMRT-UMI protocol produces highly accurate sequence datasets from diverse populations – application to HIV-1 quasispecies

2023-02-24

Abstract excerpt

Pathogen diversity resulting in quasispecies can enable persistence and adaptation to host defenses and therapies. However, accurate quasispecies characterization can be impeded by errors introduced during sample handling and sequencing which can require extensive optimizations to overcome. We present complete laboratory and bioinformatics workflows to overcome many of these hurdles. The Pacific Biosciences s ing...

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Literature Corpus work: a3999f50-9f32-58c0-9287-6efc0822c028
DOI: 10.1101/2023.02.23.529831

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