Article
VirGenA: a reference-based assembler for variable viral genomes.
Briefings in bioinformatics - 18 Jan 2019
Fedonin Gennady G, Fantin Yury S, Favorov Alexnader V, Shipulin German A, Neverov Alexey D
Abstract excerpt
Characterization of the within-host genetic diversity of viral pathogens is required for selection of effective treatment of some important viral infections, e.g. HIV, HBV and HCV. Despite the technical ability of detection, there are conflicting data regarding the clinical significance of low-frequency variants, partially because of the difficulty of their distinguishing from experimental artifacts. The issue of...
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