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Article

Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms.

PloS one - 31 Oct 2007

Suwanarusk Rossarin, Russell Bruce, Chavchich Marina, Chalfein Ferryanto, Kenangalem Enny, Kosaisavee Varakorn, Prasetyorini Budi, Piera Kim A, Barends Marion, Brockman Alan, Lek-Uthai Usa, Anstey Nicholas M, Tjitra Emiliana, Nosten François, Cheng Qin, Price Ric N

Abstract excerpt

BACKGROUND: Treatment failure of chloroquine for P. vivax infections has reached high levels in the eastern provinces of Indonesia, however, in vitro characterization of chloroquine resistance and its associated molecular profile have yet to be determined. METHODS: Using a modified schizont maturation assay we investigated the in vitro chloroquine susceptibility profile and molecular polymorphisms of P. vivax...

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Identifiers

PMID: 17971853
DOI: 10.1371/journal.pone.0001089
PMCID: PMC2034531

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