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Article

Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2006

Price Ric N, Uhlemann Anne-Catrin, van Vugt Michele, Brockman Al, Hutagalung Robert, Nair Shalini, Nash Denae, Singhasivanon Pratap, Anderson Tim J C, Krishna Sanjeev, White Nicholas J, Nosten François

Abstract excerpt

BACKGROUND: Our study examined the relative contributions of host, pharmacokinetic, and parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL). METHODS: On the northwest border of Thailand, patients with uncomplicated Plasmodium falciparum malaria were enrolled in prospective studies of AL treatment (4- or 6-dose regimens) and followed up for 42 days. Plasma lumefantrine...

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Identifiers

PMID: 16652314
DOI: 10.1086/503423
PMCID: PMC4337983

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