Article
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.
Cell communication and signaling : CCS - 26 Jul 2013
Krüger Janine, Trappiel Manuela, Dagnell Markus, Stawowy Philipp, Meyborg Heike, Böhm Christian, Bhanot Sanjay, Ostman Arne, Kintscher Ulrich, Kappert Kai
Abstract excerpt
BACKGROUND: Insulin signaling is tightly controlled by tyrosine dephosphorylation of the insulin receptor through protein-tyrosine-phosphatases (PTPs). DEP-1 is a PTP dephosphorylating tyrosine residues in a variety of receptor tyrosine kinases. Here, we analyzed whether DEP-1 activity is differentially regulated in liver, skeletal muscle and adipose tissue under high-fat diet (HFD), examined the role of DEP-1 in...
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