Article
Dehydroepiandrosterone-enhanced dual specificity protein phosphatase (DDSP) prevents diet-induced and genetic obesity.
Biochemical and biophysical research communications - 1 Jan 2000
Watanabe Tetsuhiro, Ashida Kenji, Goto Kiminobu, Nawata Hajime, Takayanagi Ryoichi, Yanase Toshihiko, Nomura Masatoshi
Abstract excerpt
Dehydroepiandrosterone (DHEA) exerts a wide variety of therapeutic effects against medical disorders, such as diabetes and obesity. However, the molecular basis of DHEA action remains to be clarified. Previously, we reported that DHEA-enhanced dual specificity protein phosphatase, designated DDSP, is one of the target molecules of DHEA. To examine the role of DDSP in DHEA signaling, we generated mice that carry a...
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