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Article

Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.

Diabetes - 1 Aug 2002

Rondinone Cristina M, Trevillyan James M, Clampit Jill, Gum Rebecca J, Berg Cathy, Kroeger Paul, Frost Leigh, Zinker Bradley A, Reilly Regina, Ulrich Roger, Butler Madeline, Monia Brett P, Jirousek Michael R, Waring Jeffrey F

Abstract excerpt

Protein tyrosine phosphatase 1B (PTP1B) has been implicated as a negative regulator of insulin action. Overexpression of PTP1B protein has been observed in insulin-resistant states associated with obesity. Mice lacking a functional PTP1B gene exhibit increased insulin sensitivity and are resistan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12145151
DOI: 10.2337/diabetes.51.8.2405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12145151-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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