Article
Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.
Cell reports - 6 Sept 2016
Forand Anne, Koumakis Eugénie, Rousseau Alice, Sassier Yohann, Journe Clément, Merlin Jean-François, Leroy Christine, Boitez Valérie, Codogno Patrice, Friedlander Gérard, Cohen Isabelle
Abstract excerpt
The liver plays a central role in whole-body lipid and glucose homeostasis. Increasing dietary fat intake results in increased hepatic fat deposition, which is associated with a risk for development of insulin resistance and type 2 diabetes. In this study, we demonstrate a role for the phosphate inorganic transporter 1 (PiT1/SLC20A1) in regulating metabolism. Specific knockout of Pit1 in hepatocytes significantly...
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