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Article

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.

Nature communications - 1 Jan 2013

Nault Jean Charles, Mallet Maxime, Pilati Camilla, Calderaro Julien, Bioulac-Sage Paulette, Laurent Christophe, Laurent Alexis, Cherqui Daniel, Balabaud Charles, Zucman-Rossi Jessica, Zucman Rossi Jessica

Abstract excerpt

Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cirrhotic preneoplastic macronodules (25%) and hepatocellular adenomas with malignant transformation in hepatocellular carcinomas (44%). In hepatocellular tumours, telomerase reverse-transcripase- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23887712
DOI: 10.1038/ncomms3218
PMCID: PMC3731665

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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