Article
The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4+ CD25+ Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney injury.
Kidney international - 1 Jan 2014
Kim Myung-Gyu, Jung Cho Eun, Won Lee Jae, Sook Ko Yoon, Young Lee Hee, Jo Sang-Kyung, Cho Won Yong, Kim Hyoung Kyu
Abstract excerpt
Recent reports suggest the presence of heat-shock protein (HSP)-reactive T cells with a regulatory phenotype in various inflammatory diseases. To test whether HSP exerts renoprotective effects through regulatory T cells (Tregs), ischemia/reperfusion injury was done with or without heat preconditioning in mice. Splenocytes from heat-preconditioned mice had Treg expansion and a reduced proliferative response upon...
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