Article
Pretransplant Recipient Circulating CD4+CD127lo/- Tumor Necrosis Factor Receptor 2+ Regulatory T Cells: A Surrogate of Regulatory T Cell-Suppressive Function and Predictor of Delayed and Slow Graft Function After Kidney Transplantation.
Transplantation - 1 Feb 2016
Nguyen Minh-Tri J P, Fryml Elise, Sahakian Sossy K, Liu Shuqing, Cantarovich Marcelo, Lipman Mark, Tchervenkov Jean I, Paraskevas Steven
Abstract excerpt
BACKGROUND: Delayed graft function (DGF) and slow graft function (SGF) are ischemia-reperfusion-associated acute kidney injuries (AKI) that decrease long-term graft survival after kidney transplantation. Regulatory T (Treg) cells are protective in murine AKI, and their suppressive function predictive of AKI in kidney transplantation. The conventional Treg cell function coculture assay is however time-consuming...
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