Article
Macrophage migration inhibitory factor (MIF) is a critical mediator of the innate immune response to Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013
Das Rituparna, Koo Mi-Sun, Kim Bae Hoon, Jacob Shevin T, Subbian Selvakumar, Yao Jie, Leng Lin, Levy Rebecca, Murchison Charles, Burman William J, Moore Christopher C, Scheld W Michael, David John R, Kaplan Gilla, MacMicking John D, Bucala Richard
Abstract excerpt
Macrophage migration inhibitory factor (MIF), an innate cytokine encoded in a functionally polymorphic genetic locus, contributes to detrimental inflammation but may be crucial for controlling infection. We explored the role of variant MIF alleles in tuberculosis. In a Ugandan cohort, genetic low expressers of MIF were 2.4-times more frequently identified among patients with Mycobacterium tuberculosis (TB)...
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