BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

doi:10.1016/j.devcel.2012.01.009

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Article

BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.

Developmental cell - 14 Feb 2012

Choi Eunhee, Park Pil-Gu, Lee Hae-Ock, Lee Yoo-Kyung, Kang Gyeong Hoon, Lee Jong Won, Han Wonshik, Lee Ho Chang, Noh Dong-Young, Lekomtsev Sergey, Lee Hyunsook

Abstract excerpt

Germline mutations that inactivate BRCA2 promote early-onset cancer with chromosome instability. Here, we report that BRCA2 regulates the spindle assembly checkpoint (SAC). Previously, we reported that BubR1 acetylation is essential for SAC activity. In this study we show that BRCA2 recruits the PCAF acetyltransferase and aids in BubR1 acetylation during mitosis. In the absence of BRCA2, BubR1 acetylation is...

Topics

Acetylation
Animals
BRCA2 Protein
Breast
Breast Neoplasms
Case-Control Studies
Cell Cycle
Cell Cycle Proteins
Cells, Cultured
Chromosomal Instability
Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo, Mammalian

Female

Fibroblasts

Fluorescent Antibody Technique

Humans

Immunoenzyme Techniques

M Phase Cell Cycle Checkpoints

Source

Open in PubMed

Identifiers

PMID: 22340495
DOI: 10.1016/j.devcel.2012.01.009

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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BRCA2 fine-tunes the spindle assembly checkpoint through reinforcement of BubR1 acetylation.PMID 22340495Read ↗

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