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Article

Human Leukocyte Antigen (HLA) Signatures and Idiosyncratic Drug-Induced Liver Injury.

International journal of molecular sciences - 2 Jan 2026

Onaciu Alexia, Grama Alina, Agoșton Ștefan, Mititelu Alexandra, Mariş Bianca, Ştefănescu Horia, Pop Tudor Lucian

Abstract excerpt

Drug-induced liver injury (DILI) remains one of the most challenging adverse drug reactions in clinical practice, particularly in its idiosyncratic form, which is not dose-dependent and is largely driven by host-specific immune and genetic factors. Recent genomic studies have revealed strong associations between certain human leukocyte antigen (HLA) alleles and susceptibility to DILI, supporting an immunogenetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41516355
DOI: 10.3390/ijms27010482
PMCID: PMC12787173

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