Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.

doi:10.1053/j.gastro.2022.11.036

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Article

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.

Gastroenterology - 1 Mar 2023

Nicoletti Paola, Dellinger Andrew, Li Yi Ju, Barnhart Huiman X, Chalasani Naga, Fontana Robert J, Odin Joseph A, Serrano Jose, Stolz Andrew, Etheridge Amy S, Innocenti Federico, Govaere Olivier, Grove Jane I, Stephens Camilla, Aithal Guruprasad P, Andrade Raul J, Bjornsson Einar S, Daly Ann K, Lucena M Isabel, Watkins Paul B

Abstract excerpt

BACKGROUND & AIMS: Drug-induced liver injury (DILI) due to amoxicillin-clavulanate (AC) has been associated with HLA-A∗02:01, HLA-DRB1∗15:01, and rs2476601, a missense variant in PTPN22. The aim of this study was to identify novel risk factors for AC-DILI and to construct a genetic risk score (GRS). METHODS: Transcriptome-wide association study and genome-wide association study analyses were performed on 444...

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PMID: 36496055
DOI: 10.1053/j.gastro.2022.11.036
PMCID: PMC9974860

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