Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA DRB115:01-DQB106:02-Restricted Human CD4+ T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Nov 2020

Tailor Arun, Meng Xiaoli, Adair Kareena, Farrell John, Waddington James C, Daly Ann, Pirmohamed Munir, Dear Gordon, Park B Kevin, Naisbitt Dean J

Abstract excerpt

Amoxicillin-clavulanate is the most common cause of idiosyncratic drug-induced liver injury (DILI). Drug-specific CD4+ T cells have been detected in patients with DILI, suggestive of an immune etiology. Furthermore, genetic associations including the human leucocyte antigen (HLA) DRB1*15:01-DQB1*06:02 haplotype influence susceptibility. Amoxicillin forms protein adducts that are postulated to activate T cells, by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amoxicillin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Cells, Cultured

Share to HLA-DRB1 Chains

Share to Leukocytes, Mononuclear

Share to Peptides

Source

Identifiers

PMID: 32777075
DOI: 10.1093/toxsci/kfaa128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA DRB1*15:01-DQB1*06:02-Restricted Human CD4+ T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts.PMID 32777075Read ↗

Human Leukocyte Antigen (HLA) Signatures and Idiosyncratic Drug-Induced Liver Injury.Semantic proximity Read ↗

Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.Semantic proximity Read ↗

Newly identified genetic variants associated with idiosyncratic drug-induced liver injury.Semantic proximity Read ↗

Analysis of drug-protein adducts and their role in drug hypersensitivitySemantic proximity Read ↗

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.Semantic proximity Read ↗

Drug-induced liver injury.Semantic proximity Read ↗

Human Leucocyte Antigen Genetics in Idiosyncratic Drug-Induced Liver Injury with Evidence Based on the Roussel Uclaf Causality Assessment MethodSemantic proximity Read ↗

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and PresentationSemantic proximity Read ↗

Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injurySemantic proximity Read ↗

Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.Semantic proximity Read ↗

Genome-Wide Association Studies for Idiosyncratic Drug-Induced Hepatotoxicity: Looking Back-Looking Forward to Next-Generation Innovation.Semantic proximity Read ↗

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.