Article
HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease.
Hepatology (Baltimore, Md.) - 1 Jun 2004
Andrade Raúl J, Lucena M Isabel, Alonso Anabel, García-Cortes Miren, García-Ruiz Elena, Benitez Rafael, Fernández M Carmen, Pelaez Gloria, Romero Manuel, Corpas Raquel, Durán José Antonio, Jiménez Manuel, Rodrigo Luis, Nogueras Flor, Martín-Vivaldi Rafael, Navarro José María, Salmerón Javier, de la Cuesta Felipe Sánchez, Hidalgo Ramón
Abstract excerpt
Drug-induced idiosyncratic liver disease (DIILD) depends largely on host susceptibility factors. Small studies support the genetic influence of human leukocyte antigen (HLA) class II molecules on the predisposition to DIILD. We sought associations between HLA-DRB and -DQB alleles and DIILD considered collectively or according to the biochemical expression of liver damage. We studied a total of 140 patients with a...
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