Article
Genes that prolong life: relationships of growth hormone and growth to aging and life span.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Aug 2001
Bartke A, Coschigano K, Kopchick J, Chandrashekar V, Mattison J, Kinney B, Hauck S
Abstract excerpt
Mutant mice with a combined deficiency of growth hormone (GH), prolactin, and thyrotropin, and knockout mice with GH resistance, live longer than their normal siblings. The extension of life span in these animals is very large (up to 65%), reproducible, and not limited to any particular genetic background or husbandry conditions. In addition to demonstrating that genes control aging in mammals, these findings...
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