Article
Association of a particular amino acid sequence of the HLA-DR beta 1 chain with HTLV-I-associated myelopathy.
European journal of immunology - 1 Jul 1990
Usuku K, Nishizawa M, Matsuki K, Tokunaga K, Takahashi K, Eiraku N, Suehara M, Juji T, Osame M, Tabira T
Abstract excerpt
Analyses of HLA-DRB1 gene using polymerase chain reaction and sequence-specific oligonucleotide probes reveal that the amino acid sequence Glu-Gln-Arg-Arg-Ala-Ala-Val at positions 69-75 of the third hypervariable region (HVR) of HLA-DR beta 1 chain is significantly associated with HTLV-I-associated myelopathy (HAM). Since the frequency of this sequence in HTLV-I carriers is almost the same as that in controls...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Genetic Predisposition to Disease
- HLA-DR Antigens
- Humans
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Paraparesis, Tropical Spastic