Article
Molecular HLA-class II typing: advantages and clinical application.
Nouvelle revue francaise d'hematologie - 1 Jan 1991
Loiseau P, al-Daccak R, David F, Colombani J
Abstract excerpt
The major histocompatibility complex (HLA system in Man) is characterized by its extensive degree of allelic polymorphism. After the serological and cellular methods, the molecular biological methods appeared to be a powerful tool in detecting HLA-class II polymorphism. Restriction fragment length polymorphism (RFLP), using restriction endonucleases, represented an efficient method of HLA-DR, DQ, and DP...
Topics
- Genotype
- Histocompatibility Antigens Class II
- Histocompatibility Testing
- Humans
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length