Article
TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing.
Nature neuroscience - 1 Sept 2013
Huang Fen, Wang Xidao, Ostertag Eric M, Nuwal Tulip, Huang Bo, Jan Yuh-Nung, Basbaum Allan I, Jan Lily Yeh
Abstract excerpt
TMEM16C belongs to the TMEM16 family, which includes the Ca(2+)-activated Cl(-) channels TMEM16A and TMEM16B and a small-conductance, Ca(2+)-activated, nonselective cation channel (SCAN), TMEM16F. We found that in rat dorsal root ganglia (DRG) TMEM16C was expressed mainly in the IB4-positive, non-peptidergic nociceptors that also express the sodium-activated potassium (K(Na)) channel Slack. Together these channel...
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