Article

Coupling of Slack and Na <sub>V</sub> 1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

2023-03-18

Abstract excerpt

<h4>ABSTRACT</h4> Quinidine has been used as an anticonvulsant to treat patients with KCNT1-related epilepsy by targeting gain-of-function KCNT1 pathogenic mutant variants. However, the detailed mechanism underlying quinidine’s blockade against KCNT1 (Slack) remains elusive. Here, we report a functional and physical coupling of the voltage-gated sodium channel Na V 1.6 and Slack. Na V 1.6 binds to and highly se...

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Literature Corpus work: fb14d702-4f62-5b16-a5c9-da77130996a7
DOI: 10.1101/2023.03.16.532982

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