Article

Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons

2023-02-14

Abstract excerpt

<h4>SUMMARY</h4> KCNT1 encodes the sodium-activated potassium channel Slack (KCNT1, K Na 1.1), an important mediator of neuronal membrane excitability. Gain-of-function (GOF) mutations in humans lead cortical network hyperexcitability and seizures, as well as very severe intellectual disability. Using a mouse model of Slack GOF-associated epilepsy, we found that both excitatory and inhibitory neurons of the cere...

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Literature Corpus work: 6abfee57-3304-55b9-a7c0-bd9926afbdbe
DOI: 10.1101/2023.02.14.528229

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