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Article

Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.

Autophagy - 1 Dec 2025

Ou Kaili, Wang Xiang, Guo Mingwei, Li Dandan, Zhang Chen, Chen Laiqiang, Hou Junqi, Jia Qingqing, Zhu Longhong, Yang Su, Li Shihua, Li Xiao-Jiang, Yin Peng

Abstract excerpt

Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington disease (HD) is characterized by the accumulation of ubiquitinated mutant HTT (huntingtin) in the central nervous system. Ubiquitination of the misfolded proteins, a common feature of the neurodegenerative diseases, is mediated by the different lysine residues on...

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Identifiers

PMID: 40818063
DOI: 10.1080/15548627.2025.2549109
PMCID: PMC12758244

Genes

HTT
UBE2N
USP29
USP49

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.PMID 40818063Read ↗

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