Article
SUMO modification of Huntingtin and Huntington's disease pathology.
Science (New York, N.Y.) - 2 Apr 2004
Steffan Joan S, Agrawal Namita, Pallos Judit, Rockabrand Erica, Trotman Lloyd C, Slepko Natalia, Illes Katalin, Lukacsovich Tamas, Zhu Ya-Zhen, Cattaneo Elena, Pandolfi Pier Paolo, Thompson Leslie Michels, Marsh J Lawrence
Abstract excerpt
Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein, Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a pathogenic fragment of Htt (Httex1p) can be modified either by small ubiquitin-like modifier (SUMO)-1 or by ubiquitin...
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