Article
A systematic evaluation of hybridization-based mouse exome capture system.
BMC genomics - 21 Jul 2013
Gao Qingsong, Sun Wei, You Xintian, Froehler Sebastian, Chen Wei
Abstract excerpt
BACKGROUND: Exome sequencing is increasingly used to search for phenotypically-relevant sequence variants in the mouse genome. All of the current hybridization-based mouse exome capture systems are designed based on the genome reference sequences of the C57BL/6 J strain. Given that the substantial sequence divergence exists between C57BL/6 J and other distantly-related strains, the impact of sequence divergence...
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