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Article

Genetic Analysis of Substrain Divergence in Non-Obese Diabetic (NOD) Mice.

G3 (Bethesda, Md.) - 3 Mar 2015

Simecek Petr, Churchill Gary A, Yang Hyuna, Rowe Lucy B, Herberg Lieselotte, Serreze David V, Leiter Edward H

Abstract excerpt

The non-obese diabetic (NOD) mouse is a polygenic model for type 1 diabetes that is characterized by insulitis, a leukocytic infiltration of the pancreatic islets. During ~35 years since the original inbred strain was developed in Japan, NOD substrains have been established at different laboratories around the world. Although environmental differences among NOD colonies capable of impacting diabetes incidence...

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Identifiers

PMID: 25740934
DOI: 10.1534/g3.115.017046
PMCID: PMC4426365

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