Article
The fine-scale architecture of structural variants in 17 mouse genomes.
Genome biology - 1 Jan 2012
Yalcin Binnaz, Wong Kim, Bhomra Amarjit, Goodson Martin, Keane Thomas M, Adams David J, Flint Jonathan
Abstract excerpt
BACKGROUND: Accurate catalogs of structural variants (SVs) in mammalian genomes are necessary to elucidate the potential mechanisms that drive SV formation and to assess their functional impact. Next generation sequencing methods for SV detection are an advance on array-based methods, but are almost exclusively limited to four basic types: deletions, insertions, inversions and copy number gains. RESULTS: By...
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