Article

Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization foci

2020-10-03

Abstract excerpt

Spreading depolarizations (SD) indicate infarct maturation and predict worse clinical outcome in ischemic stroke. We demonstrate here in rodents that brain edema formation upon ischemic stroke impairs astroglial glutamate clearance and increases the tissue area invaded by SD. The cytotoxic glutamate accumulation predisposes an extensive bulk of tissue for a yet undescribed simultaneous depolarization (SiD). We con...

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Literature Corpus work: c82c6d78-5215-5578-8d08-3a08a7039b44
DOI: 10.1101/2020.10.02.324103

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