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Article

Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids.

PloS one - 1 Jan 2013

Kenny John G, Moran Josephine, Kolar Stacey L, Ulanov Alexander, Li Zhong, Shaw Lindsey N, Josefsson Elisabet, Horsburgh Malcolm J

Abstract excerpt

Mannitol (Mtl) fermentation, with the subsequent production of acid, is a species signature of Staphylococcus aureus, and discriminates it from most other members of the genus. Inactivation of the gene mtlD, encoding Mtl-1-P dehydrogenase was found to markedly reduce survival in the presence of the antimicrobial fatty acid, linoleic acid. We demonstrate that the sugar alcohol has a potentiating action for this...

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Identifiers

PMID: 23861785
DOI: 10.1371/journal.pone.0067698
PMCID: PMC3701532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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