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Article

Metabolic reprogramming promotes Staphylococcus aureus serum resistance.

Microbiology (Reading, England) - 1 Jun 2026

Fenn Samuel J, Douglas Edward J A, Massey Ruth C

Abstract excerpt

Staphylococcus aureus is a leading cause of bloodstream infections causing an estimated 300,000 deaths worldwide. Using a functional genomics approach, our group previously identified that adaptation of S. aureus to human serum is polygenic, with a clinically occurring non-synonymous mutation (V76I) in dihydrolipoamide dehydrogenase (lpdA1/pdhD) improving bacterial survival. In this work, we establish that...

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Identifiers

PMID: 42228390
DOI: 10.1099/mic.0.001710
PMCID: PMC13229382

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