Back to search

Article

Defining the roles of pyruvate oxidation, TCA cycle, and mannitol metabolism in methicillin resistance <i>Staphylococcus aureus</i> catheter-associated urinary tract infection

2022-10-30

Abstract excerpt

Methicillin resistant Staphylococcus aureus (MRSA) is an important cause of complicated urinary tract infection (UTI) associated with the use of indwelling urinary catheters. Previous reports have revealed host and pathogen effectors critical for MRSA uropathogenesis. Here, we sought to determine the significance of specific metabolic pathways during MRSA UTI. First, we identified 16 mutants from the Nebraska tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
268aadb1-3cdb-53ab-a831-1c6101f108dd
DOI
10.1101/2022.10.28.514332
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Defining the roles of pyruvate oxidation, TCA cycle, and mannitol metabolism in methicillin resistance <i>Staphylococcus aureus</i> catheter-associated urinary tract infectionDOI 10.1101/2022.10.28.514332
Impact of the pentose phosphate pathway on metabolism and pathogenesis of Staphylococcus aureusSemantic proximity
An integrated computational and experimental study to elucidate <i>Staphylococcus aureus</i> metabolismSemantic proximity
Purine and carbohydrate availability drive <i>Enterococcus faecalis</i> fitness during wound infectionSemantic proximity
Preferential catabolism of L- vs D-serine by <i>Proteus mirabilis</i> contributes to pathogenesis and catheter-associated urinary tract infectionSemantic proximity
Human urine alters methicillin-resistant <i>Staphylococcus aureus</i> virulence and transcriptomeSemantic proximity
Genetic requirements for uropathogenic <i>E. coli</i> proliferation in the bladder cell infection cycleSemantic proximity
Uracil restores susceptibility of methicillin-resistant Staphylococcus aureus to aminoglycosides through metabolic reprogrammingSemantic proximity
Identification of a novel LysR-type transcriptional regulator in <i>Staphylococcus aureus</i> that is crucial for secondary tissue colonization during metastatic bloodstream infectionSemantic proximity
Metabolomics survey of uropathogenic bacteria in human urineSemantic proximity
Genome-wide transposon mutagenesis of Proteus mirabilis: Essential genes, fitness factors for catheter-associated urinary tract infection, and the impact of polymicrobial infection on fitness requirementsSemantic proximity
Metabolic Adaptation in Methicillin-Resistant Staphylococcus aureus PneumoniaSemantic proximity
Selective Sugar Transport Supports <i>Proteus mirabilis</i> Fitness in the Urinary TractSemantic proximity
Select a neighboring publication to make it the new centre.