Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice.

Toxicology letters - 2 May 2004

Miettinen Hanna M, Huuskonen Hannele, Partanen Anna-Maija, Miettinen Päivi, Tuomisto Jouni T, Pohjanvirta Raimo, Tuomisto Jouko

Abstract excerpt

Dioxins are persistent environmental contaminants that cause multiple disorders in laboratory animals, including teratogenesis. In mice, the most important teratogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are hydronephrosis and cleft palate. Aryl hydrocarbon receptor (AHR) mediates most of the TCDD-induced effects, but modulation of these effects by other factors such as epidermal growth factor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cleft Palate
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Eye Abnormalities

Share to Fetal Development

Share to Polychlorinated Dibenzodioxins

Share to Prenatal Exposure Delayed Effects

Share to Teratogens

Source

Identifiers

PMID: 15110080
DOI: 10.1016/j.toxlet.2004.02.009

Genes

EGFR
AHR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of epidermal growth factor receptor deficiency and 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal development in mice.PMID 15110080Read ↗

EGF and TGF-alpha expression influence the developmental toxicity of TCDD: dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice.Semantic proximity Read ↗

Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic eﬀect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in miceSemantic proximity Read ↗

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.Semantic proximity Read ↗

[Clarification of molecular targets of dioxin toxicity].Semantic proximity Read ↗

A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis.Semantic proximity Read ↗

Exposure to the aryl hydrocarbon receptor agonist dioxin disrupts formation of the muscle, nerves, and vasculature in the developing jawSemantic proximity Read ↗

Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.Semantic proximity Read ↗

Alterations in DNA methyltransferases and methyl-CpG binding domain proteins during cleft palate formation as induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.Semantic proximity Read ↗

Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD.Semantic proximity Read ↗

In Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Accelerated Terminal Differentiation in Fetal Mouse SkinSemantic proximity Read ↗

Multigenerational and Transgenerational Effects of DioxinsSemantic proximity Read ↗

Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.