Article
ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.
Molecular psychiatry - 1 Jun 2014
Boada M, Antúnez C, Ramírez-Lorca R, DeStefano A L, González-Pérez A, Gayán J, López-Arrieta J, Ikram M A, Hernández I, Marín J, Galán J J, Bis J C, Mauleón A, Rosende-Roca M, Moreno-Rey C, Gudnasson V, Morón F J, Velasco J, Carrasco J M, Alegret M, Espinosa A, Vinyes G, Lafuente A, Vargas L, Fitzpatrick A L, Launer L J, Sáez M E, Vázquez E, Becker J T, López O L, Serrano-Ríos M, Tárraga L, van Duijn C M, Real L M, Seshadri S, Ruiz A
Abstract excerpt
To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheimer's disease (AD) cases; 12 040 controls) were selected, and in Stage II these were examined in an...
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