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Article

Association study of two genetic variants in mitochondrial transcription factor A (TFAM) in Alzheimer's and Parkinson's disease.

Neuroscience letters - 15 Jun 2007

Belin Andrea Carmine, Björk Behnosh F, Westerlund Marie, Galter Dagmar, Sydow Olof, Lind Charlotta, Pernold Karin, Rosvall Lina, Håkansson Anna, Winblad Bengt, Nissbrandt Hans, Graff Caroline, Olson Lars

Abstract excerpt

Mitochondrial (mt) dysfunction has been implicated in Alzheimer's (AD) and Parkinson's disease (PD). Mitochondrial transcription factor A (TFAM) is needed for mtDNA maintenance, regulating mtDNA copy number and is absolutely required for transcriptional initiation at mtDNA promoters. Two genetic variants in TFAM have been reported to be associated with AD in a Caucasian case-control material collected from...

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Identifiers

PMID: 17537576
DOI: 10.1016/j.neulet.2007.05.010

Genes

TFAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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