Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease.

Neuroscience letters - 10 Feb 2005

Jamieson Sarra E, White Jacqueline K, Howson Joanna M M, Pask Rebecca, Smith Anne N, Brayne Carol, Evans John Grimley, Xuereb John, Cairns Nigel J, Rubinsztein David C, Blackwell Jenefer M

Abstract excerpt

Divalent cations are strongly implicated in Alzheimer's disease (AD) pathogenesis, and can regulate amyloid beta-peptide aggregation. The proton-divalent cation transporters encoded by SLC11A1 (formerly NRAMP1) on chromosome 2q35, and SLC11A2 (also known as DCT1 and DMT1) on chromosome 12q13, are expressed in the brain and regulate ion homeostasis from endosomal compartments. SLC11A1 also has pleiotropic effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Cation Transport Proteins

Share to Iron-Binding Proteins

Share to Odds Ratio

Share to Sex Factors

Source

Identifiers

PMID: 15644277
DOI: 10.1016/j.neulet.2004.10.038

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease.PMID 15644277Read ↗

ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes.Semantic proximity Read ↗

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.Semantic proximity Read ↗

The Variant T Allele of SLC2A1 rs841847 Confers Moderate Protection Against Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

Genomic Study of Taste Perception Genes in African Americans Reveals SNPs Linked to Alzheimer’s DiseaseSemantic proximity Read ↗

Vitamin D receptor and Alzheimer's disease: a genetic and functional study.Semantic proximity Read ↗

Genomic study of taste perception genes in African Americans reveals SNPs linked to Alzheimer's disease.Semantic proximity Read ↗

ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.Semantic proximity Read ↗

A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population.Semantic proximity Read ↗

Sequence variants of the aging gene CISD2 and the risk for Alzheimer's disease.Semantic proximity Read ↗

Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.Semantic proximity Read ↗

Association between divalent metal transport 1 encoding gene (SLC11A2) and disease duration in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Genetic analysis of SLC11A1 polymorphisms in multiple sclerosis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.