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Article

Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease.

Molecular neurobiology - 1 Feb 2014

Cui Jie, Jothishankar Balaji, He Ping, Staufenbiel Matthias, Shen Yong, Li Rena

Abstract excerpt

Women experience dramatic changes in hormones, mood and cognition through different periods of their reproductive lives, particularly during pregnancy and giving birth. While limited human studies of early pregnancy and motherhood showed alteration of cognitive functions in later life, researches on rodents showed a persistent improvement of learning and memory performance in females with history of giving birth...

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Identifiers

PMID: 23853041
DOI: 10.1007/s12035-013-8503-x
PMCID: PMC3891906

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