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Article

Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.

Scientific reports - 10 Jul 2024

Medegan Fagla Bani, York Jason, Christensen Amy, Dela Rosa Cielo, Balu Deebika, Pike Christian J, Tai Leon M, Buhimschi Irina A

Abstract excerpt

Apolipoprotein E (APOE) is a major cholesterol carrier responsible for lipid transport and injury repair in the brain. The human APOE gene (h-APOE) has 3 naturally occurring alleles: ε3, the common allele; ε4, which increases Alzheimer's disease (AD) risk up to 15-fold; and ε2, the rare allele which protects against AD. Although APOE4 has negative effects on neurocognition in old age, its persistence in the...

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Identifiers

PMID: 38982272
DOI: 10.1038/s41598-024-66489-w
PMCID: PMC11233746

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