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Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research

15 Jan 2021

Abstract excerpt

Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual dimorphism in AD is gaining attention as clinical data show that women are not only more likely to develop AD but also to experience worse pathology and faster cognitive decline. Pre-clinical AD research in animal models often neglects to address sexual dimorphism in evaluation of behavioral or molecular characteristics and...

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PMID: 33459720
DOI: 10.3233/jad-201014

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