Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

doi:10.1002/ijc.30687

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Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans.

International journal of cancer - 15 Jun 2017

Wang Hansong, Schmit Stephanie L, Haiman Christopher A, Keku Temitope O, Kato Ikuko, Palmer Julie R, van den Berg David, Wilkens Lynne R, Burnett Terrilea, Conti David V, Schumacher Fredrick R, Signorello Lisa B, Blot William J, Zanetti Krista A, Harris Curtis, Pande Mala, Berndt Sonja I, Newcomb Polly A, West Dee W, Haile Robert, Stram Daniel O, Figueiredo Jane C, Le Marchand Loïc

Abstract excerpt

Genome-wide association studies (GWAS) in ethnic/racial minority populations can help to fine-map previously identified risk regions or discover new risk loci because of the genetic diversity in these populations. We conducted a GWAS of colorectal cancer (CRC) in 6,597 African Americans (1,894 cases and 4,703 controls) (Stage 1) and followed up the most promising markers in a replication set of 2,041 participants...

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PMID: 28295283
DOI: 10.1002/ijc.30687
PMCID: PMC5505639

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