Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans.

doi:10.1093/hmg/ddr367

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Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans.

Human molecular genetics - 15 Nov 2011

Chen Fang, Chen Gary K, Millikan Robert C, John Esther M, Ambrosone Christine B, Bernstein Leslie, Zheng Wei, Hu Jennifer J, Ziegler Regina G, Deming Sandra L, Bandera Elisa V, Nyante Sarah, Palmer Julie R, Rebbeck Timothy R, Ingles Sue A, Press Michael F, Rodriguez-Gil Jorge L, Chanock Stephen J, Le Marchand Loïc, Kolonel Laurence N, Henderson Brian E, Stram Daniel O, Haiman Christopher A

Abstract excerpt

Genome-wide association studies (GWAS) have revealed 19 common genetic variants that are associated with breast cancer risk. Testing of the index signals found through GWAS and fine-mapping of each locus in diverse populations will be necessary for characterizing the role of these risk regions in contributing to inherited susceptibility. In this large study of breast cancer in African-American women (3016 cases...

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PMID: 21852243
DOI: 10.1093/hmg/ddr367
PMCID: PMC3196889

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