Article
Oxygen and pH-sensitivity of human osteoarthritic chondrocytes in 3-D alginate bead culture system.
Osteoarthritis and cartilage - 1 Nov 2013
Collins J A, Moots R J, Winstanley R, Clegg P D, Milner P I
Abstract excerpt
OBJECTIVE: To identify the effect of alterations in physical parameters such as oxygen and pH on processes associated with cellular redox balance in osteoarthritic chondrocytes. METHOD: Human osteoarthritic chondrocytes (HOAC) were isolated from total knee arthroplasty samples and cultured in 3-D alginate beads in four different oxygen tensions (<1%, 2%, 5% and 21% O2), at pH 7.2 and 6.2 and in the presence or...
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