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Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte Mechanotransduction

2024-06-12

Abstract excerpt

<h4>Background/Objective</h4> Articular chondrocytes synthesize and maintain the avascular and aneural articular cartilage. In vivo these cells are surrounded by a 3D pericellular matrix (PCM) containing predominantly collagen VI. The PCM protects chondrocytes and facilitates mechanotransduction. PCM stiffness is critical in transmitting biomechanical signals to chondrocytes. Various culture systems with differe...

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Literature Corpus work
3ddca173-5bf6-5240-8c49-607013049fc8
DOI
10.1101/2024.06.10.598340
Open publication

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