Article
Bone cell survival in microgravity: evidence that modeled microgravity increases osteoblast sensitivity to apoptogens.
Annals of the New York Academy of Sciences - 1 Nov 2004
Bucaro M A, Fertala J, Adams C S, Steinbeck M, Ayyaswamy P, Mukundakrishnan K, Shapiro I M, Risbud M V
Abstract excerpt
Studies were performed to evaluate the effects of modeled microgravity on the induction of osteoblast apoptosis. MC3T3-E1 osteoblast-like cells were cultured in alginate carriers in the NASA-approved high aspect ratio vessel (HARV). This system subjects the cells to a time-averaged gravitational field (vector-averaged gravity) to simulate low gravity conditions. Cells were cultured in the HARV for five days, and...
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