Article
Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage.
International journal of molecular sciences - 19 Apr 2023
Jain Lekha, Bolam Scott M, Monk A Paul, Munro Jacob T, Chen Even, Tamatea Jade, Dalbeth Nicola, Poulsen Raewyn C
Abstract excerpt
Chondrocyte phenotype and energy metabolism are altered in osteoarthritis (OA). However, most studies characterising the change in human chondrocyte behaviour in OA have been conducted in supraphysiological oxygen concentrations. The purpose of this study was to compare phenotype and energy metabolism in chondrocytes from macroscopically normal (MN) and OA cartilage maintained in 18.9% (standard tissue culture),...
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