Article

Oxidative stress and the viability of osteoblasts and cerebellar granule neurones

2006-01-01

Abstract excerpt

L-Glutamate is the major excitatory neurotransmitter in the CNS, where it activates both its ionotropic and metabotropic receptors. Excessive levels of glutamate lead to increased intracellular free calcium concentrations, which activate calcium-dependent events resulting in the production of reactive oxygen species (ROS) such as nitric oxide, superoxide and hydrogen peroxide. Glutamate-induced neuronal damage in...

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Identifiers and source

Literature Corpus work: 90ad41c2-08db-5d83-8b8b-fd07a954aceb
DOI: 10.5525/gla.thesis.71380

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