Article

Toward Standardized Ex Vivo Joint Models: Impact of Glucose and Oxygen Levels for Enhanced Tissue Maintenance

2026-02-17

Abstract excerpt

Ex vivo models bridge in vitro and in vivo systems by preserving native extracellular matrix architecture and multicellular interactions. In articular joint research, osteochondral–synovial co-cultures are particularly valuable for studying bone–cartilage crosstalk and synovial inflammatory regulation. However, a lack of standardized culture conditions regarding glucose and oxygen, two key regulators of cellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28916cf2-ab6b-574b-9b58-93e2f9626178
DOI: 10.64898/2026.02.14.704322

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Toward Standardized Ex Vivo Joint Models: Impact of Glucose and Oxygen Levels for Enhanced Tissue MaintenanceDOI 10.64898/2026.02.14.704322Read

Effect of Nutrient Metabolism on Cartilaginous Tissue FormationSemantic proximity Read

13C Metabolic Flux Analysis in Chondrocytes Reveals a Novel Switch in Metabolic Phenotype.Semantic proximity Read

Evaluation of the Anti-inflammatory and Metabolic Effects of Platelet-Rich Plasma on Equine Osteoarthritis with Cartilage-synovium Explant ModelSemantic proximity Read

Oxygen and reactive oxygen species in articular cartilage: modulators of ionic homeostasis.Semantic proximity Read

Localized oxygen control in a microfluidic osteochondral interface model recapitulates bone-cartilage crosstalk during osteoarthritisSemantic proximity Read

Differential Effects of Hypoxia versus Hyperoxia or Physoxia on Phenotype and Energy Metabolism in Human Chondrocytes from Osteoarthritic Compared to Macroscopically Normal Cartilage.Semantic proximity Read

Metabolic utilization of human osteoblast cell line hFOB 1.19 under normoxic and hypoxic conditions: A phenotypic microarray analysis.Semantic proximity Read

Metabolomic Profiling and Characterization of a Novel 3D Culture System for Studying Chondrocyte MechanotransductionSemantic proximity Read

Comparing atmospheric and hypoxic cultured mesenchymal stem cell transcriptome: implication for stem cell therapies targeting intervertebral discsSemantic proximity Read

Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine.Semantic proximity Read

Modeling the role of ATP metabolism in articular cartilage and osteoarthritisSemantic proximity Read

Osteochondral Live Slices as Physiological in-vitro Model of the Human Joint for High-throughput ApplicationsSemantic proximity Read