Article
UDP-glucuronosyltransferase 2B17 genotype and the risk of lung cancer among Austrian Caucasians.
Cancer epidemiology - 1 Oct 2013
Gruber Michaela, Le Trang, Filipits Martin, Gsur Andrea, Mannhalter Christine, Jäger Ulrich, Vanura Katrina
Abstract excerpt
BACKGROUND: The enzyme uridine diphospho glucuronosyltansferase 2B17 (UGT2B17) glucuronidates several endogenous and exogenous compounds, including carcinogens from tobacco smoke like 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanl (NNAL). UGT2B17 shows a remarkable copy number variation (CNV) and a...
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